台灣 2030 邁向智慧國家
A rewarding journey from fluid mechanics to microfluidics
In this invited talk, I will talk about my journey from fluid mechanics to microfluidics, which is an extremely rewarding experience in the past 25 years. I was trained as an engineer with expertise in fluid mechanics. Since I pursued my PhD degree at UCLA, I switched to an intriguing field working on microfluidics, which required interdisciplinary knowledge including fluid mechanics, micromachining techniques and nanotechnology. In the past 20 years, I have developed integrated microfluidic and nanotechnology systems capable of automating complicated bioprocesses on biochips for a variety of biomedical applications, including efficient screening of biomarkers (affinity reagents), and fast diagnosis of infectious diseases.
1. Biomarker screening
We explored new technology for in vitro screening of aptamers and peptides that have an affinity 100 times higher than natural antibodies, resulting in a shortened screening time (down to ~10%), reduced reagent/sample consumption, and increased efficacy of aptamer and peptide screening.
2. Fast diagnoses of infectious diseases
We have demonstrated single-biochip solutions for fast diagnosis of infectious diseases. Other important applications for virus/bacteria “subtypes” screening, antibiotics-resistant bacteria screening, and effective dose optimization of antibiotics, have also been explored.